Ir-catalyzed Sequential Asymmetric Allylic Substitution/Olefin Isomerization for the Synthesis of Axially Chiral Compounds
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چکیده
منابع مشابه
Asymmetric synthesis of axially chiral anilides by Pd-catalyzed allylic substitutions with P/olefin ligands.
As an attractive class of non-biaryl atropisomeric compounds, C-N axially chiral anilides have received considerable attention, and several methods have been successfully developed for their synthesis. Pd-catalyzed asymmetric allylic amination was proved to be an effective approach for the chiral anilide synthesis, although only moderate enantioselectivity and relatively narrow substrate scope ...
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The enantioselective fluorination of readily available cyclic allylic chlorides with AgF has been accomplished using a Pd(0) catalyst and Trost bisphosphine ligand. The reactions proceed with unprecedented ease of operation for Pd-mediated nucleophilic fluorination, allowing access to highly enantioenriched cyclic allylic fluorides that bear diverse functional groups. Evidence that supports a m...
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Bifunctional organocatalysts bearing amino and urea functional groups in a chiral molecular skeleton were applied to the enantioselective synthesis of axially chiral benzamides via aromatic electrophilic bromination. The results demonstrate the versatility of bifunctional organocatalysts for the enantioselective construction of axially chiral compounds. Moderate to good enantioselectivities wer...
متن کاملIr-catalyzed almost perfect enantioselective synthesis of helical polyaryls based on an axially-chiral sequence.
Ir-catalyzed enantioselective [2 + 2 + 2] cycloaddition of tetraynes or an octayne with monoalkynes proceeded to give helically-chiral quinquearyl and noviaryl compounds, which respectively have four and eight consecutive axial chiralities, in an almost enantiomerically pure form.
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A range of 1,2,4-trisubstituted cyclohexadienes obtained from the Birch reaction were hydrogenated asymmetrically to produce synthetically valuable chiral compounds in high enantio- and diastereoselectivity.
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ژورنال
عنوان ژورنال: Acta Chimica Sinica
سال: 2021
ISSN: ['0567-7351']
DOI: https://doi.org/10.6023/a21070320